{"id":93,"date":"2024-01-28T14:02:24","date_gmt":"2024-01-28T10:32:24","guid":{"rendered":"https:\/\/testafa.com\/testanews\/?p=93"},"modified":"2024-01-28T23:09:53","modified_gmt":"2024-01-28T19:39:53","slug":"%d8%aa%d8%b4%d8%ae%db%8c%d8%b5-%d8%b3%d8%b1%d8%b7%d8%a7%d9%86-%d9%be%d8%b1%d9%88%d8%b3%d8%aa%d8%a7%d8%aa-%d8%a8%d8%a7-%d8%a2%d8%b2%d9%85%d8%a7%db%8c%d8%b4-%d8%ae%d9%88%d9%86-%d8%ac%d8%af%db%8c%d8%af","status":"publish","type":"post","link":"https:\/\/testafa.com\/testanews\/%d8%aa%d8%b4%d8%ae%db%8c%d8%b5-%d8%b3%d8%b1%d8%b7%d8%a7%d9%86-%d9%be%d8%b1%d9%88%d8%b3%d8%aa%d8%a7%d8%aa-%d8%a8%d8%a7-%d8%a2%d8%b2%d9%85%d8%a7%db%8c%d8%b4-%d8%ae%d9%88%d9%86-%d8%ac%d8%af%db%8c%d8%af\/","title":{"rendered":"\u062a\u0634\u062e\u06cc\u0635 \u0633\u0631\u0637\u0627\u0646 \u067e\u0631\u0648\u0633\u062a\u0627\u062a \u0628\u0627 \u0622\u0632\u0645\u0627\u06cc\u0634 \u062e\u0648\u0646 \u062c\u062f\u06cc\u062f"},"content":{"rendered":"\n

\u0645\u062d\u0642\u0642\u0627\u0646 \u0645\u0648\u0633\u0633\u0647 \u0633\u0631\u0637\u0627\u0646 Dana-Farber\u060c MA\u060c \u0648 \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u062a\u0631\u0646\u062a\u0648\u060c \u0627\u06cc\u062a\u0627\u0644\u06cc\u0627\u060c \u0622\u0632\u0645\u0627\u06cc\u0634 \u062e\u0648\u0646 \u062c\u062f\u06cc\u062f\u06cc \u0631\u0627 \u0628\u0631\u0627\u06cc \u0647\u062f\u0641 \u0642\u0631\u0627\u0631 \u062f\u0627\u062f\u0646 \u0645\u06a9\u0627\u0646\u06cc\u0633\u0645\u200c\u0647\u0627\u06cc \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0645\u0648\u0631\u062f \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u062f\u0631 \u0633\u0631\u0637\u0627\u0646 \u067e\u0631\u0648\u0633\u062a\u0627\u062a \u0645\u0642\u0627\u0648\u0645 \u0628\u0647 \u0627\u062e\u062a\u0647 (CRPC or CRPC-adenocarcinoma [CRPC-adeno]) \u0627\u06cc\u062c\u0627\u062f \u06a9\u0631\u062f\u0646\u062f. \u0627\u0646\u062a\u0642\u0627\u0644 \u0628\u0647 \u0633\u0631\u0637\u0627\u0646 \u067e\u0631\u0648\u0633\u062a\u0627\u062a \u0646\u0648\u0631\u0648\u0627\u0646\u062f\u0648\u06a9\u0631\u06cc\u0646 \u0646\u0627\u062f\u0631 \u0648 \u0628\u062f\u0646\u0627\u0645 (CRPC-NE or NEPC).<\/p>\n\n\n\n

\u0633\u0644\u0648\u0644\u200c\u0647\u0627\u06cc \u0633\u0631\u0637\u0627\u0646\u06cc \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u0646\u062f \u0628\u0627 \u0645\u06a9\u0627\u0646\u06cc\u0633\u0645\u200c\u0647\u0627\u06cc \u0645\u062a\u0639\u062f\u062f \u060c \u0627\u0632 \u062c\u0645\u0644\u0647 \u0627\u0646\u062a\u0642\u0627\u0644\u200c\u0647\u0627\u06cc \u0627\u06cc\u0645\u0648\u0646\u0648\u0644\u0648\u0698\u06cc\u06a9  \u0648 \u0628\u0627\u0641\u062a\u200c\u0634\u0646\u0627\u0633\u06cc\u060c \u0648 \u06af\u0627\u0647\u06cc \u0627\u0648\u0642\u0627\u062a\u060c \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0645\u0627\u0646\u0646\u062f \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 DNA\u060c \u0627\u0632 \u0633\u06cc\u0633\u062a\u0645 \u0627\u06cc\u0645\u0646\u06cc \u0641\u0631\u0627\u0631 \u06a9\u0646\u0646\u062f . \u062a\u0634\u062e\u06cc\u0635 \u0627\u06cc\u0646 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u06cc\u0627 \u00ab\u0633\u0648\u0626\u06cc\u0686\u200c\u0647\u0627\u06cc \u0647\u0648\u06cc\u062a\u00bb \u062f\u0634\u0648\u0627\u0631 \u0627\u0633\u062a \u0648 \u0627\u063a\u0644\u0628 \u0645\u0646\u062c\u0631 \u0628\u0647 \u0633\u0631\u0637\u0627\u0646\u200c\u0647\u0627\u06cc \u0645\u0642\u0627\u0648\u0645 \u0628\u0647 \u062f\u0631\u0645\u0627\u0646 \u06cc\u0627 \u062f\u0631\u0645\u0627\u0646 \u062f\u0634\u0648\u0627\u0631 \u0645\u06cc\u200c\u0634\u0648\u062f. <\/p>\n\n\n\n

NEPC \u06cc\u06a9 \u0632\u06cc\u0631\u06af\u0631\u0648\u0647 \u062a\u0647\u0627\u062c\u0645\u06cc \u0627\u0632 \u0633\u0631\u0637\u0627\u0646 \u067e\u0631\u0648\u0633\u062a\u0627\u062a \u0645\u0642\u0627\u0648\u0645 \u0628\u0647 \u062f\u0631\u0645\u0627\u0646 \u0627\u0633\u062a. \u062a\u0634\u062e\u06cc\u0635 \u0632\u0648\u062f\u0647\u0646\u06af\u0627\u0645 \u0628\u0633\u06cc\u0627\u0631 \u0645\u0647\u0645 \u0627\u0633\u062a\u060c \u0627\u0645\u0627 \u062a\u0634\u062e\u06cc\u0635 \u0641\u0639\u0644\u06cc \u0628\u0647 \u0628\u06cc\u0648\u067e\u0633\u06cc \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 \u0645\u062a\u06a9\u06cc \u0627\u0633\u062a\u060c \u06a9\u0647 \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u0628\u0647 \u062f\u0644\u06cc\u0644 \u0646\u0627\u0647\u0645\u06af\u0646\u06cc \u0628\u0627\u0644\u0627\u06cc \u062a\u0648\u0645\u0648\u0631 \u063a\u06cc\u0631\u0642\u0627\u0628\u0644 \u0627\u0639\u062a\u0645\u0627\u062f \u0628\u0627\u0634\u062f. \u062f\u0631 \u0645\u0637\u0627\u0644\u0639\u0647\u200c\u0627\u06cc \u06a9\u0647 \u0627\u062e\u06cc\u0631\u0627\u064b \u062f\u0631 Cancer Discovery \u0645\u0646\u062a\u0634\u0631 \u0634\u062f\u0647 \u0627\u0633\u062a\u060c \u0645\u062d\u0642\u0642\u0627\u0646 \u06cc\u06a9 \u0631\u0648\u0634 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 DNA \u0631\u0627 \u0628\u0631\u0627\u06cc \u062a\u0634\u062e\u06cc\u0635 NEPC \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 DNA \u0628\u062f\u0648\u0646 \u0633\u0644\u0648\u0644\u200c\u0647\u0627\u06cc \u067e\u0644\u0627\u0633\u0645\u0627 (cfDNA) \u062a\u0648\u0635\u06cc\u0641 \u06a9\u0631\u062f\u0646\u062f.<\/p>\n\n\n

\n
\"\u0631\u0648\u0628\u0627\u0646
\u0631\u0648\u0628\u0627\u0646 \u0647\u0627\u06cc \u0622\u0628\u06cc \u0631\u0648\u0634\u0646\u06cc \u06a9\u0647 \u062f\u0631 \u0645\u0627\u0647 \u0633\u067e\u062a\u0627\u0645\u0628\u0631 \u0645\u06cc \u0628\u06cc\u0646\u06cc\u062f \u0628\u0631\u0627\u06cc \u0645\u0627\u0647 \u0645\u0644\u06cc \u0622\u06af\u0627\u0647\u06cc \u0627\u0632 \u0633\u0631\u0637\u0627\u0646 \u067e\u0631\u0648\u0633\u062a\u0627\u062a \u0627\u0633\u062a . \u0633\u0631\u0637\u0627\u0646 \u067e\u0631\u0648\u0633\u062a\u0627\u062a \u06cc\u06a9\u06cc \u0627\u0632 \u0634\u0627\u06cc\u0639 \u062a\u0631\u06cc\u0646 \u0633\u0631\u0637\u0627\u0646 \u0647\u0627 \u062f\u0631 \u062f\u0646\u06cc\u0627\u0633\u062a. <\/figcaption><\/figure>\n<\/div>\n\n\n

\u062a\u0633\u062a NEMO<\/h2>\n\n\n\n

\u067e\u0698\u0648\u0647\u0634 \u062a\u0648\u0633\u0637 \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u062a\u0631\u0646\u062a\u0648 \u0648 \u0645\u0648\u0633\u0633\u0647 \u0633\u0631\u0637\u0627\u0646 \u062f\u0627\u0646\u0627-\u0641\u0627\u0631\u0628\u0631 \u0648 \u0628\u0631\u062e\u06cc \u062f\u06cc\u06af\u0631 \u0627\u0632 \u0645\u062a\u062e\u0635\u0635\u06cc\u0646 \u0632\u06cc\u0631 \u0646\u0638\u0631 \u062f\u06a9\u062a\u0631 \u0641\u0631\u0627\u0646\u0686\u0633\u06a9\u0627 \u062f\u0645\u06cc\u06a9\u0644\u06cc\u0633 \u0627\u0646\u062c\u0627\u0645 \u0634\u062f\u0647 \u0627\u0633\u062a.<\/p>\n\n\n\n

\n

\u062f\u06a9\u062a\u0631 \u062f\u0645\u06cc\u06a9\u0644\u06cc\u0633 \u0645\u06cc \u06af\u0648\u06cc\u062f:<\/p>\n“\u0627\u06cc\u0646 \u0622\u0632\u0645\u0627\u06cc\u0634 \u0628\u0647 \u0637\u0648\u0631 \u0627\u0646\u062a\u062e\u0627\u0628\u06cc cfDNA \u062f\u0631 \u067e\u0644\u0627\u0633\u0645\u0627\u06cc \u062e\u0648\u0646 \u0631\u0627 \u0628\u0631\u0627\u06cc \u0642\u0637\u0639\u0627\u062a DNA \u0645\u0631\u062a\u0628\u0637 \u0628\u0631\u0631\u0633\u06cc \u0645\u06cc \u06a9\u0646\u062f \u0648 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0622\u0646\u0647\u0627 \u0631\u0627 \u0627\u0646\u062f\u0627\u0632\u0647 \u06af\u06cc\u0631\u06cc \u0645\u06cc \u06a9\u0646\u062f.” \u0627\u0632 \u0622\u0646\u062c\u0627\u06cc\u06cc \u06a9\u0647 \u062a\u0639\u062f\u0627\u062f \u0645\u0646\u0627\u0637\u0642 \u0645\u062a\u06cc\u0644\u0647 \u0645\u0648\u0631\u062f \u0646\u06cc\u0627\u0632 \u0628\u0631\u0627\u06cc \u062a\u0645\u0627\u06cc\u0632 \u0628\u06cc\u0646 \u0633\u0644\u0648\u0644\u200c\u0647\u0627\u06cc \u0646\u0631\u0645\u0627\u0644\u060c CRPC-adeno \u0648 NEPC \u06a9\u0645 \u0627\u0633\u062a\u060c \u067e\u0627\u0646\u0644 \u0698\u0646\u200c\u0647\u0627\u06cc\u06cc \u06a9\u0647 \u062a\u0648\u0633\u0637 \u0622\u0632\u0645\u0627\u06cc\u0634 \u062a\u0648\u0627\u0644\u06cc\u200c\u06cc\u0627\u0628\u06cc \u0645\u06cc\u200c\u0634\u0648\u0646\u062f \u062d\u062f\u0627\u0642\u0644 \u0648 \u06a9\u0627\u0631\u0622\u0645\u062f \u0647\u0633\u062a\u0646\u062f.\u00bb<\/cite><\/blockquote>\n\n\n\n

NEMO \u06a9\u0633\u0631 \u062a\u0648\u0645\u0648\u0631 \u0648 \u0641\u0646\u0648\u062a\u06cc\u067e \u062a\u0648\u0645\u0648\u0631 (\u06cc\u0627 CRPC-adeno \u06cc\u0627 NEPC) \u0631\u0627 \u06af\u0632\u0627\u0631\u0634 \u0645\u06cc\u200c\u06a9\u0646\u062f. \u06a9\u0633\u0631 \u062a\u0648\u0645\u0648\u0631 \u0628\u0631 \u0627\u0633\u0627\u0633 \u0646\u0633\u0628\u062a DNA \u062a\u0648\u0645\u0648\u0631 \u0628\u0647 DNA \u0637\u0628\u06cc\u0639\u06cc \u062f\u0631 \u0646\u0645\u0648\u0646\u0647 \u062e\u0648\u0646 \u0627\u0633\u062a. \u0641\u0646\u0648\u062a\u06cc\u067e \u062a\u0648\u0645\u0648\u0631 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u06cc\u06a9 \u0627\u0645\u062a\u06cc\u0627\u0632 \u062f\u0631 \u06cc\u06a9 \u0632\u0646\u062c\u06cc\u0631\u0647 \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u062d\u0627\u0644\u062a \u0631\u0648\u0646\u0648\u06cc\u0633\u06cc \u0648 \u0645\u0646\u0627\u0637\u0642 \u0631\u0648\u06cc cfDNA \u06af\u0632\u0627\u0631\u0634 \u0645\u06cc \u0634\u0648\u062f.<\/p>\n\n\n\n

\u0628\u0647 \u0646\u0638\u0631 \u06cc\u06a9\u06cc \u0627\u0632 \u062f\u0633\u062a \u0627\u0646\u062f\u0631\u06a9\u0627\u0631\u0627\u0646 \u0627\u06cc\u0646 \u067e\u0698\u0648\u0647\u0634: \u00ab[NEMO] \u0646\u0647 \u062a\u0646\u0647\u0627 \u0641\u0646\u0648\u062a\u06cc\u067e \u0639\u0635\u0628\u06cc \u063a\u062f\u062f \u062f\u0631\u0648\u0646 \u0631\u06cc\u0632 \u0631\u0627 \u0627\u0646\u062a\u062e\u0627\u0628 \u0645\u06cc \u06a9\u0646\u062f\u060c \u0628\u0644\u06a9\u0647 \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u0632\u06cc\u0631\u06af\u0631\u0648\u0647 \u0647\u0627\u06cc \u0645\u06cc\u0627\u0646\u06cc \u0631\u0627 \u0646\u06cc\u0632 \u0627\u0646\u062a\u062e\u0627\u0628 \u06a9\u0646\u062f\u060c \u0632\u06cc\u0631\u0627 \u062a\u0648\u0645\u0648\u0631\u0647\u0627 \u0627\u0632 \u06cc\u06a9 \u0632\u06cc\u0631\u06af\u0631\u0648\u0647 \u0628\u0647 \u0632\u06cc\u0631\u06af\u0631\u0648\u0647 \u062f\u06cc\u06af\u0631 \u0645\u0646\u062a\u0642\u0644 \u0645\u06cc \u0634\u0648\u0646\u062f.<\/p>\n\n\n\n

\u0639\u0645\u0644\u06a9\u0631\u062f \u0648 \u0645\u06cc\u0632\u0627\u0646 \u0645\u0648\u0641\u0642\u06cc\u062a<\/h3>\n\n\n\n

\u0627\u06cc\u0646 \u062a\u06cc\u0645 \u067e\u0627\u0646\u0644 NEMO \u0631\u0627 \u0631\u0648\u06cc \u06af\u0631\u0648\u0647\u200c\u0647\u0627\u06cc \u0628\u0627\u0644\u06cc\u0646\u06cc \u0645\u0633\u062a\u0642\u0644 \u0628\u0627 \u0632\u06cc\u0631\u06af\u0631\u0648\u0647\u200c\u0647\u0627\u06cc \u0634\u0646\u0627\u062e\u062a\u0647 \u0634\u062f\u0647 \u0633\u0631\u0637\u0627\u0646 \u067e\u0631\u0648\u0633\u062a\u0627\u062a \u0622\u0632\u0645\u0627\u06cc\u0634 \u06a9\u0631\u062f\u0646\u062f. \u067e\u0627\u0646\u0644 \u0628\u06cc\u0648\u067e\u0633\u06cc \u0645\u0627\u06cc\u0639\u060c \u0632\u06cc\u0631\u06af\u0631\u0648\u0647\u200c\u0647\u0627\u06cc CRPC-adeno \u0648 NEPC \u0631\u0627 \u0628\u0627 \u0633\u0637\u062d \u062f\u0642\u062a \u0628\u0627\u0644\u0627\u06cc\u06cc \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u06a9\u0631\u062f (AUC > 0.93). NEMO \u0647\u0645\u0686\u0646\u06cc\u0646 \u0628\u0627 \u0646\u062a\u0627\u06cc\u062c \u0628\u0627\u0644\u06cc\u0646\u06cc \u0627\u0632 \u062f\u0648 \u06a9\u0627\u0631\u0622\u0632\u0645\u0627\u06cc\u06cc \u067e\u06cc\u0634\u0631\u0648\u0646\u062f\u0647 \u0631\u0648\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u0627\u0646\u0648\u0627\u0639 CRPC \u062a\u0647\u0627\u062c\u0645\u06cc \u062a\u0623\u06cc\u06cc\u062f \u0634\u062f.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u0622\u0632\u0645\u0627\u06cc\u0634 \u062e\u0648\u0646 \u062c\u062f\u06cc\u062f \u0632\u06cc\u0631\u06af\u0631\u0648\u0647 \u0647\u0627\u06cc \u067e\u06cc\u0634\u0631\u0641\u062a\u0647 \u0633\u0631\u0637\u0627\u0646 \u067e\u0631\u0648\u0633\u062a\u0627\u062a \u0631\u0627 \u062a\u0634\u062e\u06cc\u0635 \u0645\u06cc \u062f\u0647\u062f. \u0631\u0648\u0634 \u0628\u06cc\u0648\u067e\u0633\u06cc \u0645\u0627\u06cc\u0639 \u0627\u0632 DNA \u0628\u062f\u0648\u0646 \u0633\u0644\u0648\u0644 \u0645\u062a\u06cc\u0644\u0647 \u0628\u0631\u0627\u06cc \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc\u060c \u0637\u0628\u0642\u0647 \u0628\u0646\u062f\u06cc \u0648 \u06a9\u0645\u06cc\u062a \u0628\u0627\u0631 \u0648 \u0646\u0648\u0639 \u062a\u0648\u0645\u0648\u0631 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0645\u06cc \u06a9\u0646\u062f.<\/p>\n","protected":false},"author":1,"featured_media":106,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[26,25],"class_list":["post-93","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-testnews","tag-26","tag-25"],"_links":{"self":[{"href":"https:\/\/testafa.com\/testanews\/wp-json\/wp\/v2\/posts\/93","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/testafa.com\/testanews\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/testafa.com\/testanews\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/testafa.com\/testanews\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/testafa.com\/testanews\/wp-json\/wp\/v2\/comments?post=93"}],"version-history":[{"count":7,"href":"https:\/\/testafa.com\/testanews\/wp-json\/wp\/v2\/posts\/93\/revisions"}],"predecessor-version":[{"id":109,"href":"https:\/\/testafa.com\/testanews\/wp-json\/wp\/v2\/posts\/93\/revisions\/109"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/testafa.com\/testanews\/wp-json\/wp\/v2\/media\/106"}],"wp:attachment":[{"href":"https:\/\/testafa.com\/testanews\/wp-json\/wp\/v2\/media?parent=93"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/testafa.com\/testanews\/wp-json\/wp\/v2\/categories?post=93"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/testafa.com\/testanews\/wp-json\/wp\/v2\/tags?post=93"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}